Superoxide Dismutase Inactivation in Pathophysiology of Asthmatic Airway Remodeling and Reactivity

Superoxide dismutase inactivation in pathophysiology of asthmatic airway remodeling and reactivity.

Airway hyperresponsiveness and remodeling are defining features of asthma. We hypothesized that impaired superoxide dismutase (SOD) antioxidant defense is a primary event in the pathophysiology of hyperresponsiveness and remodeling that induces apoptosis and shedding of airway epithelial cells. Mechanisms leading to apoptosis were studied in vivo and in vitro. Asthmatic lungs had increased apop...

Superoxide dismutase Superoxide dismutase

Sustained Decrease in Superoxide Dismutase Activity Underlies Constrictive Remodeling

Paulo F. Leite, Alexandre Danilovic, Patricia Moriel, Katia Dantas, Stefan Marklund, Ana Paula After Balloon Injury in Rabbits Sustained Decrease in Superoxide Dismutase Activity Underlies Constrictive Remodeling Print ISSN: 1079-5642. Online ISSN: 1524-4636 Copyright © 2003 American Heart Association, Inc. All rights reserved. Greenville Avenue, Dallas, TX 75231 is published by the American He...

Role of histamine in airway remodeling of asthmatic guinea pig.

To investigate the role of histamine in airway remodeling, 50 healthy guinea pigs were divided into 5 groups: control group: nebulized inhalation of distilled water for 8 weeks; asthma model group: nebulized inhalation of ovalbumin (OVA) for 8 weeks after sensitization; continued asthma model group: nebulized inhalation of OVA for 14 weeks after sensitization; histamine group: nebulized inhalat...

Notch Signaling: Linking Embryonic Lung Development and Asthmatic Airway Remodeling.

Lung development is mediated by assorted signaling proteins and orchestrated by complex mesenchymal-epithelial interactions. Notch signaling is an evolutionarily conserved cell-cell communication mechanism that exhibits a pivotal role in lung development. Notably, both aberrant expression and loss of regulation of Notch signaling are critically linked to the pathogenesis of various lung disease...